The COVID-19 turns the immune system against itself: the immune system attacks its own body

COVID-19 turns the immune system against itself

Throughout the entire period of the pandemic, the scientists are trying to figure out the behavior of the human immune system during the infection with the coronavirus. The immunologists joined in the fight against the COVID-19 and are trying to understand для why some people get sick with serious consequences for the body, while others recover quickly. The main task was to produce antibodies. They are powerful proteins that can disable and kill invading pathogens, including viruses.

But the scientists identified a strange feature of the proteins of the immune system. The specialists are concerned about the sporadic identification of autoreactive antibodies. Instead of targeting disease-causing microbes in the human body, they target the tissues of people with the most severe forms of coronavirus.

Previous studies demonstrated the incredible ability of these antibodies to cause dangerous blood clots. Now, the researchers are directly linking the involvement of the manifestation of critical moments with the components of viral immune defense in patients in extremely serious condition. Emory University’s immunologist Ignacio Sansa noted that he and his colleagues are studying the immune response that is responsible for producing antibodies when infected with the COVID-19.

A group of scientists previously investigated a range of immune responses that promote the production of antibodies in serious diseases such as lupus, and more recently in severe cases of coronavirus. The experts described the reaction of many patients to the COVID-19 as autoimmune.

But the scientists failed to confirm the formation of autoantibodies that are formed in latent antiviral reactions. It turns out that the antibodies can have their own tastes, and they are associated with specific types of diseases. For example, people with lupus often have antibodies that target their own DNA, the molecules that make up the human genome. And patients with rheumatoid arthritis are unlikely to have such antibodies.

They are more likely to have antibodies in their blood that target other antibodies. During a study of data from 52 patients, the scientists found that none of them had autoimmune diseases. But they were tested during infection for the presence of autoantibodies found in various diseases.

The result amazed the scientists. More than half of the patients tested positive for antibodies. It means that their immune systems during the coronavirus produced antibodies that attack their own tissues.