Pomegranate peel extract will help in the treatment of coronavirus: it can prevent infection

Pomegranate peel extract will help treat coronavirus

The pomegranate peel extract has a unique quality: it can become an inhibitor of the SARS-CoV-2 virus. The coronavirus is recognized as a severe acute respiratory syndrome causing the COVID-19. To date, over 58.5 million people were infected with it worldwide, accounting for about 1.38 million deaths. The disease caused a global crisis in health care and in the economy.

The situation is complicated by the fact that to nowadays there are no effective and safe vaccines that can prevent the infection’s spreading. The scientists around the world are trying to create a new drug that would help fight the virus.

Relia Suručić of the University of Banja Luka in Bosnia and Herzegovina concluded that a more detailed study of the use of pomegranate peel extract as a potential new inhibitor should be done. The virus is rapidly transmitted from person to person, having four major structural proteins along with accessory proteins. Penetrating into the cells of the respiratory tract through one of them, the virus begins to interact with receptors that are present in the respiratory system.

Glycoprotein S has two functional subunits. Known as S, they are an amino acid, a terminal subunit that binds to the ACE2 receptor on the cell surface. The second is S2, it interacts with the host cell membrane and ensures the fusion of the cell membranes and the virus.

As a result, viral particles are able to enter the cell. There are specific proteases in the cell, they are able to destroy both subunits to ensure the process of fusion and penetration. The scientists do not exclude that natural ingredients may have the ability to prevent the spread of infection.

For example, pomegranate that is known for its effectiveness in treating grade 2 diabetes, cardiovascular disease, and many inflammatory processes, contains unique phytobiotics. They are remarkable in that they have properties that have anti-inflammatory, antioxidant, hypoglycemic, antimicrobial effects.

Pomegranate extracts are known for their benefits against viruses, including influenza, herpes, and HIV viruses, and even hepatitis C. They can prevent the virus from entering and RNA transcription.

Reference: Suručić, R., Tubić, B., Stojiljković, M.P. et al. Computational study of pomegranate peel extract polyphenols as potential inhibitors of SARS-CoV-2 virus internalization. Mol Cell Biochem (2020). DOI: 10.1007/s11010-020-03981-7