Geneticists prolong youth: new methods of gene therapy can stop aging

Geneticists have found a way to prolong the body's youth

The scientists announced the development of a new gene therapy that may slow aging and increase lifespan. Body wear is directly related to cellular aging. But it can be genetically regulated. There are several genes associated with aging, they play a role, and the researchers intend to study it. But in the course of previous research, it turned out that these genes contribute to the development of diseases that most often occur in old age.

How many such genes are there in the human genome? What are their molecular organisms and is it possible to stop the aging process with their help? The experts from the Chinese Academy of Sciences and Peking University are trying to answer these and other questions.

For the first time, they were able to identify genes that could provide a completely new approach to the treatment of aging and related pathologies. The experts performed a genome-wide CRISPR-based stem cell screening. They found over a hundred genes that could be candidates for genes that promote cellular rejuvenation.

Among them was KAT7, a gene that was identified as one of the main targets in reducing cellular senescence. Depletion of KAT7 attenuates cellular senescence, while overexpression of KAT7 accelerates cellular senescence. The accumulation of senescent cells in the body leads to general aging of the body.

If, for the purpose of prevention, aging cells are removed, then the degeneration of cells decreases and the duration of the cells newly formed in their place increases. In an experiment on mice, gene therapy showed that the putative gene is indeed capable of extending the life of cells and thereby prolonging the youth and working capacity of the body.

The results of the new study indicate that the KAT7 gene may cause decreased aging of human hepatocytes and decreased expression of the SASP genes, suggesting that these interventions can be applied in a clinical setting.

Reference: “A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence” by Wei Wang, Yuxuan Zheng, Shuhui Sun, Wei Li, Moshi Song, Qianzhao Ji, Zeming Wu, Zunpeng Liu, Yanling Fan, Feifei Liu, Jingyi Li, Concepcion Rodriguez Esteban, Si Wang, Qi Zhou, Juan Carlos Izpisua Belmonte, Weiqi Zhang, Jing Qu, Fuchou Tang and Guang-Hui Liu, 6 January 2021, Science Translational Medicine. DOI: 10.1126/scitranslmed.abd2655