New immune cells discovered by the scientists at the La Jolla Institute of Immunology are able to cope with allergic reactions and asthma. A conducted study has opened a new way in the fight against the allergic manifestations. The world is full of house dust and even the most thorough cleaning does not allow to deal with it completely. In the body of every person there are cells that cope with the allergic manifestations, including the dust.
And although most people do not suffer from allergies, those people who have it can only rely on their own immunity. Allergic manifestations are most often sneezing, coughing, runny nose, tearing. In a small number of people, it can manifest itself more severely - in the form of asthma that threatens life.
The specialists of the Institute of Immunology dedicated their new research to that theme. They identified a subtype of T cells that control the development of allergic immune responses and asthma in response to house dust and other allergens. Gregory Semois, one of the researchers, noted that new subsets of immune cells and new therapeutic possibilities have been discovered.
A new kind of immune cell may be one of many unknown mechanisms that explains why healthy people do not develop inflammation when they inhale allergens. According to Professor Pandurangan Vijayananda, the study emphasizes the power of objective approaches to unicellular genomics to discover a new biologist.
The scientific work is based on the experience of the laboratory, where the relationship of gene expression with the development of diseases is studied. During the study, the scientists used the database of immune epitopes to find out how the immune system interacts with allergens, such as house dust mites.
For that, the tools of the genomic revolution, single-celled RNA-seq, were used. It allowed the most accurate determination of genes and T cell molecules that produce a response to HDM allergens.
Four groups of people with asthma and allergies to HDM, with asthma but no allergies to HDM, allergies only to HDM, and healthy people without allergies were tested. The analysis showed that T cells are more common in the blood of people with asthma. They are enriched with a group of molecules that increase the immune potential of these cells.